2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130420
    Azido-PEG5-PFP ester 1818294-48-2
    Azido-PEG5-PFP ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG5-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-PFP ester
  • HY-130892
    (+)-Biotin-PEG2-hydrazide 2413847-26-2
    (+)-Biotin-PEG2-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    (+)-Biotin-PEG2-hydrazide
  • HY-141079
    N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 2107273-84-5
    N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7
  • HY-161499
    Boc-NHCH2-Ph-pyrimidine-NH2 3040121-15-8
    Boc-NHCH2-Ph-pyrimidine-NH2 is the linker for PROTAC molecule XYD198 (HY-161498).
    Boc-NHCH2-Ph-pyrimidine-NH2
  • HY-140555
    N-Boc-N-bis(PEG3-azide) 1258939-38-6
    N-Boc-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-Boc-N-bis(PEG3-azide)
  • HY-140577
    N-Me-N-bis-PEG3 342818-95-5
    N-Me-N-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Me-N-bis-PEG3
  • HY-147205D
    Biotin-PEG-OH (MW 10000)
    Biotin-PEG-OH (MW 10000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG-OH (MW 10000)
  • HY-141196
    N-Boc-PEG36-alcohol
    N-Boc-PEG36-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-PEG36-alcohol
  • HY-140392
    Boc-N-Amido-PEG5-MS 2128735-28-2
    Boc-N-Amido-PEG5-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-N-Amido-PEG5-MS
  • HY-140061
    Propargyl-PEG11-methane 2250411-18-6
    Propargyl-PEG11-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG11-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG11-methane
  • HY-140732
    Dioxoisoindolin-O-PEG-OH (MW 2000)
    Dioxoisoindolin-O-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Dioxoisoindolin-O-PEG-OH (MW 2000)
  • HY-134751
    VES-POFP
    VES-POFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    VES-POFP
  • HY-129773
    Phthalimide-PEG4-PDM-OTBS
    Phthalimide-PEG4-PDM-OTBS is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-PDM-OTBS can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    Phthalimide-PEG4-PDM-OTBS
  • HY-113921
    m-PEG4-propargyl 1101668-39-6
    m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    m-PEG4-propargyl
  • HY-140393
    N-(Tos-PEG4)-N-bis(PEG4-Boc) 2112737-74-1
    N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Tos-PEG4)-N-bis(PEG4-Boc)
  • HY-140425
    Boc-Aminooxy-PEG1-C2-NH2 1844894-82-1
    Boc-Aminooxy-PEG1-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminooxy-PEG1-C2-NH2
  • HY-140581
    N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester 2100306-76-9
    N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester
  • HY-138341
    Benzyl-PEG10-THP
    Benzyl-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG10-THP
  • HY-138707
    Azido-PEG7-NHS ester
    Azido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-NHS ester
  • HY-140243
    1,1,1-Trifluoroethyl-PEG4-amine 1872433-72-1
    111-Trifluoroethyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    1,1,1-Trifluoroethyl-PEG4-amine
PROTAC Linkers Isoform Comparison

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